Cerebral Vascular Disease and Neurovascular Injury in Ischemic Stroke
نویسندگان
چکیده
منابع مشابه
Cerebral Vascular Disease and Neurovascular Injury in Ischemic Stroke.
The consequences of cerebrovascular disease are among the leading health issues worldwide. Large and small cerebral vessel disease can trigger stroke and contribute to the vascular component of other forms of neurological dysfunction and degeneration. Both forms of vascular disease are driven by diverse risk factors, with hypertension as the leading contributor. Despite the importance of neurov...
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Background and Purpose Stroke is one of the most common causes of mortality and morbidity in the Western world. It results from the occlusion of a cerebral artery followed by severe disturbances in blood supply through microvessels to brain tissue. Despite an extensive literature its pathophysiology is poorly understood, and this has severely impeded the logical development of therapy. Methods ...
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Respiratory Pattern Disturbances in Ischemic Cerebral Vascular Disease • Impedance pneumography was used to monitor respiratory rates and patterns in 49 patients with acute ischemic cerebral vascular disease. Nine patients had clinical evidence of bilateral ischemic cerebral disease. In one of these, normal respiratory pattern was present at all times; in five, there was intermittent Cheyne-Sto...
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Although the innate immune response to induce postischemic inflammation is considered as an essential step in the progression of cerebral ischemia injury, the role of innate immunity mediator NLRP3 in the pathogenesis of ischemic stroke is unknown. In this study, focal ischemia was induced by middle cerebral artery occlusion in NLRP3(-/-), NOX2(-/-), or wild-type (WT) mice. By magnetic resonanc...
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Ischemic stroke is a devastating complication of bone fracture. Bone fracture shortly after stroke enhances stroke injury by augmenting inflammation. We hypothesize that bone fracture shortly before ischemic stroke also exacerbates ischemic cerebral injury. Tibia fracture was performed 6 or 24 hours before permanent middle cerebral artery occlusion (pMCAO) on C57BL/6J mice or Ccr2RFP/+Cx3cr1GFP...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2017
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.116.308427